MEASUREMENT OF BONE GROWTH IN OSTEOPETROSIS

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  • 1 January 1964
    • journal article
    • research article
    • Vol. 28  (10) , 236-+
Abstract
Day-old chicks were injected with 0.2 ml. of a suspension of lymphomatosls virus which was known to cause osteopetrosls in a high percentage of susceptible birds. A comparable number of uninoculated chicks were kept for controls. Alizarin red S was administered for the purpose of marking the bones in order to measure the rate of growth of normal bone and the osteopetrotlc bone. The dye was given at 27, 41 and 55 days of age. In this experiment it was found that a layer of normal bone was formed on the surface of the tibia at a rate of 0.25 mm. per week but in the largest osteopetrotlc lesion that was found in any chicken spongy bone was formed at a rate greater than 1 mm. per week. Alizarin red S was irritating to tissue and was toxic when given intravenously.

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