Lack of association between manic‐depressive illness and a highly polymorphic marker from GABRA3 gene
- 9 October 1995
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 60 (5) , 434-435
- https://doi.org/10.1002/ajmg.1320600514
Abstract
We have carried out an association study between a dinucleotide repeat polymorphism in GABRA3 gene and manic‐depressive illness in a Spanish population. This may be an important candidate gene for bipolar affective disorders since it is located in the Xq28 region, previously implicated in linkage studies. In addition, severe GABergic alterations have been reported in patients. We have not found significant differences between controls and patients in allele frequencies or genotypes.Keywords
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