Interferon Induction in Murine Peritoneal Macrophage by Stimulation with Lactobacillus acidophilus

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Abstract
Induction of interferon for a kind of dairy lactic acid bacteria, Lactobacillus acidophilus (L. acidophilus), was investigated in murine peritoneal macrophage (MØ) cultures. Lactobacillus acidophilus JCM 1034, 1132T, 1229 and 2125 induced IFN (12–34 I.U./ml) in MØ cultures in vitro. Strain 1132T‐ and 2125‐induced IFNs were characterized as IFNα/β by treatment with anti‐IFNs serum. The results indicate that the inducing activity of IFNs may be one of the available biological parameters for designating the dairy products containing L. acidophilus as “physiologically functional foods.”