Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins

Publisher Website
Google Scholar
Abstract
Previously, three proteins have been separately identified as the mouse epidermal growth factor binding protein (EGF-BP). We have identified and sequenced the coding regions of three distinct genes encoding these EGF-BPs from the BALB/c strain. The genes are all members of the glandular kallikrein gene family, which encodes a highly homologous group of serine proteases. Expression of the EGF-BP genes was detected in mouse salivary gland only and was at a relatively similar level for each gene. The isolation of three distinct genes from the one mouse strain indicates that the conflicting data previously reported in the literature are not a result of allelic polymorphisms or strain differences.