Ampicillin trihydrate in foals: Serum concentrations and clearance after a single oral dose

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Abstract
Five foals 2-3 days old were given a single oral dose of ampicillin trihydrate [antibacterial drug] (20 mg/kg body wt [bwt]). Serum ampicillin concentrations were measured serially over a 24 h period. The study was repeated in the same foals at 16-21 days old. The mean peak serum ampicillin concentration at 2-3 days old was 5.0 .mu.g/ml at 1 h after treatment; the mean peak serum concentration at 16-21 days old was 2.7 .mu.g/ml at 2 h. The concentrations steadily declined and ampicillin was not detected in the serum from any of the foals by 24 h. Serum clearance averaged 17.7 ml/min per kg at 2-3 days and 35.8 ml/min per kg at 16-21 days.