Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose

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Abstract
Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) i.m. at a dosage of 20 mg/kg body wt. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 .mu.g/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 and 1.81 .mu.g/ml at 6 and 4 h, respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 .mu.g/ml at 4 h.