ADDISON'S DISEASE AND PEPTIC ULCER

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Abstract
A 49-year-old negro housewife with Addison''s disease is described, in whom a gastric ulcer developed during treatment with 25 mg of corti-sone acetate daily. It is suggested that adrenal hormone is neces-sary for, but not the cause of the development of peptic ulcer, and that in the presence of an excess of adrenal hormone the stomach and/or duodenum may be sensitized to respond by secre-tory hyperactivity and/or ulceration to stimuli which would ordinarily be innocuous.