Exploiting C3-symmetry in the dynamic coordination of a chiral trisoxazoline to copper(ii): improved enantioselectivity, and catalyst stability in asymmetric lewis acid catalysis
- 16 September 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 40,p. 5115-5117
- https://doi.org/10.1039/b509571a
Abstract
Chiral C3-symmetric trisoxazolines are highly efficient stereodirecting ligands in enantioselective CuII Lewis acid catalysis which is based on the concept of a stereoelectronic hemilability of the divalent copper; in direct comparison with the analogous bisoxazoline systems they are more efficient in the enantioselective α-amination as well as the enantioselective Mannich reaction of prochiral β-ketoesters.Keywords
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