Cortisol-Dihydrotachysterol Antagonism in a Patient with Hypoparathyroidism and Adrenal Insufficiency: Apparent Inhibition of Bone Resorption

Publisher Website
Google Scholar
Abstract
This report describes a case of chronic mucocutaneous candidiasis with associated hypopara thyroidism and acutely developed adrenocortical insufficiency. The latter was heralded by hypercalcemia. Upon the institution of cortisol therapy, while still under the effects of a vitamin D analog, dihydrotachysterol (DHT), the patient exhibited severe hypocalcemia and tetany. Since calcium intake was minimal during this period of presumed corticosteroid-DHT antagonism, it is suggested that the cortisol disturbed calcium homeostasis by inhibiting bone calcium resorption.