The Effect of Immunoglobulin Occurring on Human Sperm In Vivo on the Human Sperm/Hamster Ova Penetration Assay

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Abstract
We selected 91 infertile men who were tested for increased sperm‐associated immunoglobulin and also tested in the human sperm/hamster ova penetration assay. There was a statistically significant association between the presence of increased sperm‐associated IgG alone (p = 0.0218) and both sperm‐associated IgG and A (p = 0.0187) when correlated with the failure to penetrate any hamster ova. There was a trend but no statistical significance when sperm‐associated immunoglobulin A alone was present. There was a trend but no statistical relationship between the presence of sperm‐associated immunoglobulin and the sperm penetration assay when the criteria for normality of the sperm penetration assay was a 15% or greater ovum penetration rate.