Structure of the Carboxyl-Terminal Half of Human α2-Plasmin Inhibitor Deduced from That of cDNA
- 1 October 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 100 (5) , 1399-1402
- https://doi.org/10.1093/oxfordjournals.jbchem.a121846
Abstract
A 1.7 kilobase cDNA clone isolated from a human liver cDNA library contained 822 nucleotides encoding the carboxyl-terminal 274 amino acid sequence of α2-plasmin inhibitor, a stop codon and a 3′ noncoding region of 0.9 kilobases. The amino acid sequence deduced from the cDNA shows 29–31% homology with those of other plasma protease inhibitors. The inhibitor's putative reactive-site peptide bond was Met-Ser, and the Met residue was located at the 91st position from the carboxyl-terminal end. The plasminogen bindlng site was located in the carboxylterminal region.This publication has 17 references indexed in Scilit:
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