Intranuclear inclusions in a myopathy of late onset

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Abstract
Filamentous intranuclear inclusions in a [human] case of late onset myopathy are described. The filaments were usually in parallel array although occasionally they were haphazardly arranged in bundles ranging up to 5 .mu. in length. The filaments were .apprx. 120 .ANG. in diameter and were separated by a space measuring 180-220 .ANG.. Possible explanations of their occurrence in the nucleoplasm are discussed, including possible origin from the cytoplasm as a result of invagination of nuclear membrane and intranuclear entrapment of myofibrils from the cytoplasm. Their appearance does not suggest any recognizable structure such as myofilaments or virus. It is possible that the filaments are protein newly synthesized as a direct result of virus infection with invasion of the muscle cell nuclei.