Melanosis of the Prostate Gland: Report of a Case with Neoplastic Epithelium Involvement

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Abstract
Prostate gland melanosis is an uncommon lesion and the precise histogenesis is unclear. Melanin may be found within melanocytes in the prostatic stroma, within prostatic epithelium and, rarely, in both locations. Stromal dendritic cells contain premelanosomes and melanosomes, suggesting primary melanin production. The melanogenic potential of prostatic epithelial cells was not conclusively established. An example of human prostatic melanosis is presented in which stromal and epithelial components were found. This dual distribution of melanin was regarded as an indication that melanin in the epithelial cells results phagocytosis of melanin from stromal melanocytes as a secondary phenomenon. Melanin pigment was identified not only within hyperplastic prostatic epithelium, but was also found in the epithelial component of a well differentiated prostatic adenocarcinoma.

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