Acetylator phenotype in idiopathic systemic lupus erythematosus
Open Access
- 1 May 1980
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 23 (5) , 569-573
- https://doi.org/10.1002/art.1780230508
Abstract
The acetylator phenotypes of 21 patients from New York City and 29 patients from Israel with idiopthic systemic lupus erythematosus (SLE) were determined with dapsone or isoniazid. Thrity were slow acetylators, 17 were rapid, and 3 indeterminate. These cases plus published studies of acetylator phenotypes in indiopathic SLE show a worldwide distribution of 150 slow to 77 rapid instead of the expected 122:105 (P, < 0.001). The relationship between acetylator phenotype and possible etiologic agents is discussed.This publication has 34 references indexed in Scilit:
- Antibodies to Nuclear Antigens in Patients Treated with Procainamide or AcetylprocainamideNew England Journal of Medicine, 1979
- Prevalence of HLA-DRw2 Not Increased in Systemic Lupus ErythematosusNew England Journal of Medicine, 1979
- Acetylator phenotype in spontaneous SLE and rheumatoid arthritis.Annals of the Rheumatic Diseases, 1979
- The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control TrialNew England Journal of Medicine, 1978
- B-Lymphocyte Alloantigens Associated with Systemic Lupus ErythematosusNew England Journal of Medicine, 1978
- Effect of Acetylator Phenotype on the Rate at Which Procainamide Induces Antinuclear Antibodies and the Lupus SyndromeNew England Journal of Medicine, 1978
- Normal distribution of acetylation phenotypes in systemic lupus erythematosusArthritis & Rheumatism, 1978
- Disease and Acetylation PolymorphismClinical Pharmacokinetics, 1977
- Clinicopathological study of a patient with procainamide-induced systemic lupus erythematosus.Annals of the Rheumatic Diseases, 1976
- Acetylator Phenotype in Patients with Hydralazine‐induced Lupoid SyndromeActa Medica Scandinavica, 1976