IN VITRO CYTOTOXICITY OF LYMPHOCYTE SUBPOPULATIONS AGAINST AUTOLOGOUS HUMAN BLADDER TUMOR CELLS

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Abstract
The in vitro cytotoxicity of unfractionated blood lymphocytes and T and non-T lymphocytes, respectively, was tested against autologous tumor cells from 21 patients with grade III-IV urothelial bladder carcinomas. Generally, little or no cytotoxicity was seen. However, some differences in autologous cytotoxicity between T and non-T lymphocytes were detectable. Four of 21 patients had cytotoxic non-T lymphocytes against autologous bladder tumor cells. The effector cells evidently are primarily non-T lymphocytes; cytotoxicity seemingly appears at lower levels of T lymphocytes in unfractionated lymphocyte preparations.