Nuclear structure in cancer cells
Top Cited Papers
- 1 September 2004
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 4 (9) , 677-687
- https://doi.org/10.1038/nrc1430
Abstract
Nuclear architecture - the spatial arrangement of chromosomes and other nuclear components - provides a framework for organizing and regulating the diverse functional processes within the nucleus. There are characteristic differences in the nuclear architectures of cancer cells, compared with normal cells, and some anticancer treatments restore normal nuclear structure and function. Advances in understanding nuclear structure have revealed insights into the process of malignant transformation and provide a basis for the development of new diagnostic tools and therapeutics.Keywords
This publication has 127 references indexed in Scilit:
- Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding DomainPublished by Elsevier ,2004
- The SWI/SNF complex — chromatin and cancerNature Reviews Cancer, 2004
- Inheritance of gene density–related higher order chromatin arrangements in normal and tumor cell nucleiThe Journal of cell biology, 2003
- Spatial proximity of translocation-prone gene loci in human lymphomasNature Genetics, 2003
- RNA Polymerase III Transcripts and the PTB Protein Are Essential for the Integrity of the Perinucleolar CompartmentMolecular Biology of the Cell, 2003
- Combined confocal and wide-field high-resolution cytometry of fluorescent in situ hybridization-stained cellsCytometry, 2001
- Initial sequencing and analysis of the human genomeNature, 2001
- Nucleolar size indicates the rapidity of cell proliferation in cancer tissuesThe Journal of Pathology, 2000
- Preferential Expression of NuMA in the Nuclei of Proliferating CellsExperimental Cell Research, 2000
- hnRNP proteins and B23 are the major proteins of the internal nuclear matrix of HeLa S3 cellsJournal of Cellular Biochemistry, 1996