One-Pot Synthesis of Benzo[b]furan and Indole Inhibitors of Tubulin Polymerization
Top Cited Papers
- 4 May 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 45 (12) , 2670-2673
- https://doi.org/10.1021/jm020077t
Abstract
Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.Keywords
This publication has 10 references indexed in Scilit:
- The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4Published by Elsevier ,2001
- A Novel Palladium-Mediated Coupling Approach to 2,3-Disubstituted Benzo[b]thiophenes and Its Application to the Synthesis of Tubulin Binding AgentsOrganic Letters, 2001
- In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrugBritish Journal of Cancer, 1999
- A new anti-tubulin agent containing the benzo[b]thiophene ring systemPublished by Elsevier ,1999
- Selective Cleavage of Isopropyl Aryl Ethers by Aluminum Trichloride†The Journal of Organic Chemistry, 1998
- Colchicine: 1998 updateSeminars in Arthritis and Rheumatism, 1998
- Docetaxel.Journal of Clinical Oncology, 1995
- 2-Substituted-3-acylindoles through the Palladium-Catalysed Carbonylative Cyclization of 2-Alkynyltrifluoroacetanilides with Aryl Halides and Vinyl TriflatesTetrahedron, 1994
- The length of a junction between the B and Z conformations in DNA is three base pairs or lessBiochemistry, 1989
- Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4Cellular and Molecular Life Sciences, 1989