The effect of iodoacetic acid and other substances on the disappearance of glucose from shed blood

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Abstract
Iodoacetic acid and bromacetic acid are equally efficient in preventing the disappearance of glucose from shed blood. The effective concn., however, is higher than is necessary to prevent lactic acid formation in muscle. Chloracetic acid. a-iodopropionic acid and iodoethyl alcohol act similarly but less efficiently, and the first 2 of these react, though relatively slowly, with glutathione. Their effect on blood, like that of iodoacetic acid and of bromacetic acid, is counteracted by added glutathione. Iodoethyl alcohol, on the other hand, does not react with glutathione to liberate HI, and its effect on the disappearance of blood glucose is not prevented by added glutathione. Both iodo-acetic acid and iodo-ethyl alcohol have an inhibitory action on blood phosphatase.

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