Determination of the Gene Sequence of Poliovirus with Pactamycin
- 1 November 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (11) , 2852-2856
- https://doi.org/10.1073/pnas.68.11.2852
Abstract
By examination of the virus-specific polypeptides formed after the addition of pactamycin, an inhibitor of protein chain initiation, to infected cells, it has been possible to tentatively locate the virus coat proteins at the amino terminus of the large, virus-specific protein precursor, and, therefore, to assign the coat protein cistron to the 5' end of the RNA.Keywords
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