Symptomatic Treatment of Painful Neuropathy

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Abstract
Pain resulting from diffuse and focal neuropathies, such as painful diabetic neuropathy (PDN) and postherpetic neuralgia (PHN), is a relatively common but difficult to manage clinical problem. Neuropathy occurs in more than 50% of patients with diabetes who have been hyperglycemic for more than 15 years,1 and about 10% of patients with diabetic neuropathy are troubled with persistent dysesthesias or pain. Unfortunately, drug treatment for PDN is often unsatisfactory, as eloquently demonstrated by the large number of drugs that patients will have taken in an attempt to seek relief.