Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex
Open Access
- 15 November 2004
- journal article
- Published by The Company of Biologists in Development
- Vol. 131 (22) , 5639-5647
- https://doi.org/10.1242/dev.01428
Abstract
Recent findings implicate embryonic signaling centers in patterning the mammalian cerebral cortex. We used mouse in utero electroporation and mutant analysis to test whether cortical signaling sources interact to regulate one another. We identified interactions between the cortical hem, rich in Wingless-Int (WNT) proteins and bone morphogenetic proteins (BMPs), and an anterior telencephalic source of fibroblast growth factors (FGFs).Keywords
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