Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitutions of Leucine 22

This publication has 36 references indexed in Scilit:

• Determination by Raman Spectroscopy of the pKa of N5 of Dihydrofolate Bound to Dihydrofolate Reductase: Mechanistic Implications
  Biochemistry, 1994
• Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency
  Biochemistry, 1992
• Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis
  Biochemistry, 1991
• CHAIN — A crystallographic modeling program
  Journal of Molecular Graphics, 1988
• Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow.
  The Journal of Experimental Medicine, 1987
• Theoretical transition structures for hydride transfer to methyleneiminium ion from methylamine and dihydropyridine. On the nonlinearity of hydride transfers
  Journal of the American Chemical Society, 1987
• Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells
  Nature, 1986
• Gene transfer in intact animals
  Nature, 1980
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
  Analytical Biochemistry, 1976
• A program for efficient integration of rate equations and least-squares fitting of chemical reaction data
  Computers and Biomedical Research, 1972