Chronic ACTH Administration and the Development of Hypertension in Rats

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Abstract
The results of the present study demonstrate that the chronic infusion of ACTH stimulates endogenous steroidogenesis, suppresses PRA, and leads to the development of hypertension in normal rats; the hypertension is reversible upon cessation of ACTH infusion. This experimental model should prove useful for studying adrenal mechanisms involved in the pathogenesis of hypertension.