COMPARATIVE EFFECT OF ACTH, CORTISONE AND DCA ON RENAL FUNCTION, ELECTROLYTE EXCRETION AND WATER EXCHANGE IN NORMAL DOGS

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Abstract
The inadequacies of our knowledge of the role of adrenocortical hormones in the regulation of electrolyte and water metabolism are becoming increasingly apparent (Gaunt, et al., 1949; Ingle, 1950; Sayers, 1950). Extensive and numerous observations on the action of DCA have been reported (Ragan, et al., 1940; Ferrebee, et al., 1941; Mulinos, et al., 1941; Zierler and Lilienthal, 1948; Gaudino and Levitt, 1949; Davis, et al., 1951; Luft and Sjögren, 1952; Sjogren, 1952), but data on the effect of 11,17-oxysteroid hormones in the dog are meager (Thorn, et al., 1941; Davis, et al., 1951; Roberts and Pitts, 1952). The latter studies were with cortisone and observations with ACTH are necessary before adequate evaluation of the relation of the ACTH-adrenocortical system to salt metabolism can be made. An important consideration which has been neglected in most studies with ACTH and cortisone in the dog