SUSCEPTIBILITY TO EXPERIMENTAL PYELONEPHRITIS WHEN HORMONAL HYPERTENSION IS PREVENTED BY HYPOTENSIVE DRUGS *

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Abstract
Rats with desoxycorticosterone-saline induced hypertension have again been found to inhibit marked renal vascular damage and increased susceptibility to pyelonephritis. These studies lend support to the hypothesis that various injuries, including nephrosclerosis, predispose to human pyelonephritis and that pyelonephritis is superimposed upon hypertensive disease more frequently than is usually suspected. In other rats on the same regimen to which hypotensive drugs (hydralazine and syrosingopine) were added, blood pressure was at or near normal levels when measured at weekly intervals, renal vascular lesions were minimized, and no increased susceptibility to pyelonephritis was demonstrated.