Effect of Reserpine (Serpasil) and Hydralazine (Apresoline) on Experimental Steroid Hypertension

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Abstract
Effects of reserpine and hydralazine, singly and combined, were studied in rats given DCA and salt under conditions which without therapy led to a hypertensive syndrome and 100% mortality in an average of 71 days. Either drug given alone had some protective effect as judged by a relative reduction in blood pressure and an increased survival time. When given in combination, reserpine and hydralazine supplemented each other, and for periods up to 6 months reduced blood pressure, delayed or prevented renal and vascular pathological changes, enhanced the growth rate and more than tripled the average survival time. In some cases the appearance of "metacorticoid" hypertension was apparently prevented.