The Effect of Testosterone, Adrenal Steroids and Prolactin on Erythropoiesis

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Abstract
Both prolactin and 7-a-methyltestosterone, alone and in combination, increased the red cell volume and plasma volume of mice following their prolonged Injection. Both increased the incorporation of Fe59 into erythrocytes of polycythemic mice and potentiated the effect of erythropoietin. Prednisolone acetate had no erythropoietic effect of its own and did not enhance the erythropoietic effect of testosterone or the combination of testosterone and prolactin. These hormones may act at several levels potentiating both the elaboration of erythropoietin and its action on the stem cell, but requiring its presence for their action to become apparent.