Androgens and Erythropoiesis

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Abstract
ERYTHROLEUKOBLASTIC changes in the peripheral blood have been associated with extramedullary hematopoiesis. In recent years a large proportion of patients manifesting such changes associated with hepatosplenomegaly have been classified as having agnogenic myeloid metaplasia.1 Most of them have had evidence of myelosclerosis and myelofibrosis of the bone marrow. Often, the disorder follows as a sequela to polycythemia vera. In the patient with myeloid metaplasia the characteristic findings of chronic or acute myelocytic leukemia may eventually develop. As one views the spectrum of altered bone-marrow activity, the pattern may be part of a generalized myeloproliferative disorder of bone marrow.2 In this . . .