Calcitonin stimulates gluconeogenesis in fasted rats.

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Abstract
The effect of calcitonin (CT) on gluconeogenesis was studied in fasted rats. The s.c. administration of CT (80 MRC [Medical Research Council] mU/100 g BW [body wt]) produced a significant increase in serum glucose concentration and a corresponding decrease in serum lactic acid, free fatty acid and alanine concentrations. These alterations were dose-dependent (20 and 40 MRC mU/100 g BW). The serum glucose concentration was significantly elevated by a single i.p. injection of alanine (100 mg/100 g BW). This increase was markedly enhanced by CT administration, and the appreciable effect was observed at a dose of 20 MRS mU/100 g BW. The significant increase in serum glucose concentration caused by the injections of lactate, pyruvate and .alpha.-ketoglutarate (100 mg/100 g BW, respectively) was further enhanced by CT administration. CT apparently stimulates gluconeogenesis in fasted rats.

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