PHARMACOKINETICS OF GENTAMICIN IN BIRDS OF PREY

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (7) , 1245-1247
Abstract
The pharmacokinetics of gentamicin, including half-life, apparent volume of distribution, total body clearance and fraction of drug absorbed from i.m. injection sites, were determined in 3 spp. of birds of prey (red-tailed hawks, great horned owls and golden eagles). Significant differences (P < 0.05) between species were found for the half-life and total body clearance values for this broad-spectrum antibacterial drug. The values for apparent volume of distribution and fraction absorbed did not differ among species and were similar to those reported in mammals. Rapid and relatively complete absorption from i.m. injection sites resulted in high bioavailability. After i.v. administration of 10 mg of gentamicin/kg of body weight, serum concentrations > 12 .mu.g/ml were present for at least 2 h and > 2 .mu.g/ml for 4-6 h. Evidently, an i.m. dose of 2.5 mg of gentamicin/kg given every 8 h should provide therapeutic serum concentrations of gentamicin in the 3 spp.