Synthesis of Adenosine 3':5'-Cyclic Monophosphate in Salmonella typhimurium Growing in Continuous Culture

Open Access
Publisher Website
Google Scholar
Abstract
Cyclic AMP synthesis in continuous culture of S. typhimurium was not equal to the level predicted from studies in batch culture. Apparently, synthesis of the nucleotide is influenced by factors other than inhibition or activation of adenylate cyclase (EC 4.6.1.1) consequent to transport of C sources. The putative activation of adenylate cyclase may be limiting when bacteria grow in C-limited chemostats. The proposed activator or perhaps adenylate cyclase per se may be less stable under these conditions. Alternatively, synthesis of adenylate cyclase or some activator protein may be repressed in response to longer generation times.