Effect of Cyclophosphamide on Interstitial Nephritis and Tubule Cell Proliferation in NZB/NZW Mice

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Abstract
The effect of cyclophosphamide on renal interstitial mononuclear cell infiltration and renal tubule cell (TC) proliferation has been examined in (NZB × NZW)F1 hybrid (B/W) and control mice. TC proliferation was measured by tritiated thymidine (3HTdr) injection, autoradiographic examination of kidney sections, and enumeration of labeled tubular cells. Cyclophosphamide administered 2 months before sacrifice virtually obliterated interstitial infiltration and significantly decreased tubule cell proliferation at 3, 5, 7, 9, and 12 months of age.