Quantitative Determination of 3, 4-Dihydroxymandelic Acid (Doma) in Human Urine

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Abstract
A high-voltage paper electrophoretic method of measuring the concentration of doma in urine was described. The recovery rate of doma was 76.0.[plus or minus]7.9% and the error of measurement was[plus or minus] 10.6% by this method. Using this method, it was revealed that the excretion of doma in 24 hours urine amounted to 40[image]150 [gamma] in 11 normal subjects, and that it was markedly increased in 5 cases of pheochromocytoma. The urinary excretion ratio of catecholamines and their metabolites by this method in the 5 cases of pheochromocytoma was always in good agreement with the reported values obtained by measurements using the istope technique.

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