THE ISOLATION OF A MOUSE LEUKAEMIA VIRUS RESEMBLING FRIEND VIRUS

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Abstract
SUMMARY: A virus (WM1‐B strain) was isolated from mice infected with the WM1 virus. It was filterable through a gradocol membrane of 320 mμ. A.P.D. and was sensitive to ether and to heating at 56°C. for 30 minutes.Macroscopic signs of infection in Q.I.M.R. mice were splenomegaly, hepatomegaly and lymphadenopathy. The leucocyte levels showed a marked increase, with mononuclear cells predominant. Erythroblasts were present in peripheral blood. Histologically, proliferation of reticulum cells was associated with erythropoiesis and was restricted mainly to spleen, liver and bone marrow, The virus persisted in the serum of infected mice. The mortality was almost 100 p.c.The WM1‐B virus was apparently a strain of Friend virus. It was neutralized by anti‐serum to Friend virus and the experimental disease it produced resembled that described with Friend virus.