A Molecular Defect in the Vasopressin V2-Receptor Gene Causing Nephrogenic Diabetes Insipidus
Open Access
- 27 May 1993
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 328 (21) , 1534-1537
- https://doi.org/10.1056/nejm199305273282105
Abstract
Fundamental to the maintenance of water balance in humans is the rate at which the kidneys excrete free water, which is primarily regulated by arginine vasopressin. The antidiuretic action of arginine vasopressin requires the binding of the hormone to the renal-type (V2) vasopressin receptor, which results in the activation of adenylate cyclase, the generation of cyclic AMP (cAMP), and increased reabsorption of water across the apical membrane of the cells of the renal collecting duct1.Keywords
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