Berberine: Complex with DNA
- 7 November 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3906) , 755-757
- https://doi.org/10.1126/science.166.3906.755
Abstract
A complex of calf-thymus DNA with berberine sediments in the analytical ultracentrifuge. The DNA produced systematic changes in the absorption spectrum of berberine which suggest that single alkaloid molecules bind to DNA. Flow dichroism of purines and pyrimidines and of berberine in the complex with DNA had the same signs and magnitudes. Berberine shifted the thermal strand separation profile of DNA to higher temperatures. Therefore, the alkaloid forms a complex with DNA, probably by intercalation.Keywords
This publication has 15 references indexed in Scilit:
- Ethidium bromide induced mutation of yeast mitochondria: Complete transformation of cells into respiratory deficient non-chromosomal “petites”Biochemical and Biophysical Research Communications, 1968
- Effect of Berberine Sulphate on Entamoeba histolyticaNature, 1967
- Evidence for intercalation of chloroquine into DNABiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
- Interaction of polynuclear aromatic hydrocarbons, 4‐nitroquinoline 1‐oxides, and various dyes with DNABiopolymers, 1966
- DNA: Reaction with ChloroquineScience, 1965
- INTERACTION BETWEEN NUCLEIC ACIDS AND BERBERINE SULFATEThe Journal of cell biology, 1962
- The influence of deoxyribonucleic acid on ultraviolet and visible light absoption of berberineArchives of Biochemistry and Biophysics, 1959
- Spectrophotometric studies on the interaction of nucleic acids with aminoacridines and other basic dyesExperimental Cell Research, 1954
- THE NATURE OF THE INTERACTION OF NUCLEIC ACIDS AND NUCLEI WITH BASIC DYESTUFFSCold Spring Harbor Symposia on Quantitative Biology, 1947
- Die bactericide Wirkung der Extrakte und Alkaloide des Schöllkrautes (Chelidonium maius) auf grampositive pathogene MikroorganismenMedical Microbiology and Immunology, 1928