Chemotherapeutic Properties of Anthramycin

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Abstract
Anthramycin, a crystal-line antibiotic derived from a thermophilic actinomycete, was evaluated in the form of its methyl ether (n) for in vivo chemotherapeutic properties employing transplanted tumors, gram-positive and gram-negative bacteria, fungi, viruses, protozoa and helminths. Its effect in vitro against mammalian cell cultures was studied. Anthramycin was active in vivo against the following transplanted rodent and human tumors: Ehrlich carcinoma, both solid and ascitic forms, Sarcoma 180, Walker carcinosarcoma 256, H. Ep. No. 3, and H. Ad. No. 1. The substance was without effect against leukemia L 1210, ascitic form. In addition to its antitumor properties, anthramycin was found to exert a definite chemotherapeutic effect in experimental infections with Trichomonas vaginalis, Endamoeba histolytica and Syphacia obvelata. Anthramycin was found to be without chemotherapeutic activity in experimental infections with bacteria, fungi, viruses, and other protozoan and helminthic infections studied. Anthramycin displayed in vitro cytotoxic properties when tested against mammalian cell cultures.

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