XYZ Effect in Strain of Origin: EO771 Carcinoma in C57 BL/6 Mice

Publisher Website
Google Scholar
Abstract
Fifty-two C57 BL/6 mice from the Jackson Memorial Laboratory were inoculated with EO771 mammary carcinoma tissue carried in C57 black/6 mice from the same laboratory. As expected all 52 died from the growth of the neoplasm. However, 26 of the mice which had been pretreated with frozen non-viable EO771 tumor (xyz factor) from the Jackson Laboratory developed a significantly increased rate of tumor growth and earlier mortality than the 26 controls not so treated. The effectiveness for transplanted tumors of the xyz factors in the inbred strain of origin, as demonstrated above, suggests the possibility that spontaneous tumors could be enhanced in the host of origin by xyz factors if such were present in them.