Antistaphylococcal Activity of Dalbavancin, an Experimental Glycopeptide
Open Access
- 1 February 2005
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (2) , 770-772
- https://doi.org/10.1128/aac.49.2.770-772.2005
Abstract
Dalbavancin, tested against 146 staphylococci, was more potent than other drugs tested, with an MIC at which 50% of staphylococci were inhibited of 0.03 μg/ml and an MIC at which 90% of staphylococci were inhibited of 0.06 μg/ml by microdilution. For all strains, MICs of vancomycin, linezolid, ranbezolid, oritavancin, daptomycin, and quinupristin-dalfopristin were ≤4.0 μg/ml. Dalbavancin was bactericidal at four times the MIC against all six strains tested.Keywords
This publication has 25 references indexed in Scilit:
- Activities of Dalbavancin In Vitro and in a Rabbit Model of Experimental Endocarditis Due to Staphylococcus aureus with or without Reduced Susceptibility to Vancomycin and TeicoplaninAntimicrobial Agents and Chemotherapy, 2004
- Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolatesDiagnostic Microbiology and Infectious Disease, 2004
- Initial Quality Control Evaluations for Susceptibility Testing of Dalbavancin (BI397), an Investigational Glycopeptide with Potent Gram-Positive ActivityJournal of Clinical Microbiology, 2003
- In Vitro Activities of Dalbavancin and Nine Comparator Agents against Anaerobic Gram-Positive Species and CorynebacteriaAntimicrobial Agents and Chemotherapy, 2003
- Antipneumococcal and Antistaphylococcal Activities of Ranbezolid (RBX 7644), a New Oxazolidinone, Compared to Those of Other AgentsAntimicrobial Agents and Chemotherapy, 2003
- In Vitro Activities of Six Quinolones and Mechanisms of Resistance in Staphylococcus aureus and Coagulase-Negative StaphylococciAntimicrobial Agents and Chemotherapy, 2001
- OxazolidinonesDrugs, 2000
- Molecular epidemiology of quinolone resistance and comparative in vitro activities of new quinolones against EuropeanStaphylococcus aureusisolatesFEMS Immunology & Medical Microbiology, 1999
- Ciprofloxacin Resistance in Methicillin-Resistant Staphylococcus AureusClinical Journal of Sport Medicine, 1998
- Methicillin-ResistantStaphylococcus aureus in EuropeEuropean Journal of Clinical Microbiology & Infectious Diseases, 1994