THE EFFECTS OF QUIET STANDING ON SOLUTE DIURESIS 1

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Abstract
Infusions of mannitol, Na bicarbonate and Na phosphate were administered to normal subjects in the supine position and during quiet standing. Observations were made of changes in the plasma volume, the serum electrolytes, and the urinary excretion of the loading solute, and of Na and other electrolytes. Quiet standing partially inhibited the sodium diuresis induced by the admn. of mannitol, but did not interfere with the increased excretion of Na caused by infusions of NaHCO3 or Na2HPO4. The results with mannitol indicate the operation of internal regulatory mechanisms on the intrinsic renal responses which characterize solute diuresis. The results with NaHCO3 and Na phosphate are discussed in relation to the unique limitations imposed by these salts on the tubular reabsorption of Na.