A COMPARATIVE STUDY OF THE EFFECTS OF OXYGEN LACK ON PERIPHERAL NERVE

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Abstract
The time required to extinguish by anoxia the action potential of peripheral nerve is less in mammalian nerve than in the nerves of lower animals. Time of survival in mins. of nerves without oxygen is: rabbit 24, cat 33, dog 33, Rana pipiens 170, R. catesbiana 230, lobster Panidirus interruptus 76, crayfish Cambarus clarkii more than 9 hrs. The rate of O2 uptake in emm./g./hr. of peripheral nerves from these animals is: rabbit 245, cat 193, R. pipiens 50, R. catesbiana 29, P. interruptus 70, and C. clarkii 13. The product of the survival time and the O2 uptake rate is approximately constant for the various spp. investigated (6500). The inverse relationship between survival time and O2 uptake rate demonstrated by this constant is further verified by the facts that (a) the survival time varies inversely and the O2 uptake rate directly with temp.; (b) near the cut end of the nerve the survival time is shorter and the O2 uptake rate greater than normal.

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