Effect of Aldosterone Antagonist on in vitro Production of Aldosterone and Corticosterone in Rats.

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Abstract
Male and female Sprague-Dawley rats were treated with the spirolactone, SC-8109, known to be an aldosterone antagonist. After 12 weeks of treatment the animals were sacrificed. Adrenal glands were incubated in vitro and total alpha-ketolic, as well as individual, steroids were determined. Male and female adrenal incubates from SC-8109-treated rats contained significantly more aldosterone and less corticosterone than incubates from those injected with the sesame oil vehicle. Male rats treated with SC-8109 showed particularly striking increase in aldosterone production.