Transplacental Japanese Encephalitis Virus (JEV) Infection in Mice During Consecutive Pregnancies

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Abstract
Transplacental transmission of Japanese encephalitis virus (JEV) was demonstrated in consecutive pregnancies of mice. Pregnant mice inoculated i.p. with JEV transmitted the virus to the fetus. When such female mice were mated again after 6 mo., the virus could be isolated from the fetuses of the ensuing pregnancy. The incidence of abortion was increased significantly, though the neonatal deaths were considerably less than during the 1st pregnancy. Intrauterine infection occurred in spite of the presence of hemagglutination inhibition antibodies against JEV in the preconceptional sera of the mice. The value of such a system for further investigations of the pathogenesis of JEV infection during pregnancy in humans is discussed.

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