Treatment of Gout

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Abstract
GOUT is a consequence of hyperuricemia. It is of interest that our generally accepted upper limit of normal for serum unite, a concentration greater than 7 mg per 100 ml, corresponds closely to the solubility of sodium urate in human plasma at pH 7.4. Concentrations higher than this represent a supersaturated solution, a system in which the "excess" urate will, under appropriate circumstances, precipitate. Resultant urate deposition occurs in a variety of tissues, including synovium, cartilage, tendon, subchondral bone and renal parenchyma. The almost universal association of microcrystalline monosodium urate in acute gouty synovial effusions implies that inflammatory arthritis, the . . .