Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions
- 1 February 1999
- journal article
- review article
- Published by S. Karger AG in Hormone Research in Paediatrics
- Vol. 51 (2) , 53-67
- https://doi.org/10.1159/000023315
Abstract
The insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and IGFBP proteases regulate somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogens whose actions are determined by the availability of free IGFs to interact with IGF receptors. IGFBPs comprise a family of six proteins that bind IGFs with high affinity and specificity and thereby regulate IGF-dependent actions. IGFBPs have recently emerged as IGF-independent regulators of cell growth. Cleavage of IGFBPs by specific proteases modulate levels of free IGFs and IGFBPs and thereby their actions. IGFBP-related proteins (IGFBP-rPs) bind IGFs with low affinity and also play important roles in cell growth and differentiation. The GH-IGF-IGFBP axis is complex and powerful. Future research on its physiology promises exciting insights into cell biology as well as therapies for diseases such as cancer and diabetes mellitus.Keywords
This publication has 32 references indexed in Scilit:
- Insulin-like Growth Factor (IGF)-binding Protein 5 Forms an Alternative Ternary Complex with IGFs and the Acid-labile SubunitJournal of Biological Chemistry, 1998
- All-trans-retinoic Acid Increases Transforming Growth Factor-β2 and Insulin-like Growth Factor Binding Protein-3 Expression through a Retinoic Acid Receptor-α-dependent Signaling PathwayPublished by Elsevier ,1997
- ESM-1 Is a Novel Human Endothelial Cell-specific Molecule Expressed in Lung and Regulated by CytokinesJournal of Biological Chemistry, 1996
- Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer CellsJournal of Biological Chemistry, 1996
- Induction of the growth inhibitor IGF-binding protein 3 by p53Nature, 1995
- Insulin-like growth factors and their binding proteins: biological actionsEndocrine Reviews, 1995
- Insulin-like growth factor-binding protein-2 concentrations in cerebrospinal fluid and serum of children with malignant solid tumors or acute leukemiaJournal of Clinical Endocrinology & Metabolism, 1994
- Cell Adhesion Activity of a 30-kDa Major Secreted Protein from Human Bladder Carcinoma CellsBiochemical and Biophysical Research Communications, 1994
- The HOX complex neighbored by the EVX gene, as well as two other homeobox‐containing genes, the GBX‐class and the EN‐class, are located on the same chromosomes 2 and 7 in humansFEBS Letters, 1993
- The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteinsJournal of Clinical Endocrinology & Metabolism, 1992