Studies on chemical carcinogens. XVIII. Acetylation of carcinogenic 4-(N-hydroxy-N-methylamino)quinoline 1-oxide.

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Abstract
Treatment of carcinogenic and mutagenic 4-(N-hydroxy-N-methylamino)quinoline 1-oxide with acetic anhydride gave 4-(N-acetoxy-N-acetoxymethylamino)quinoline and 4-(N-acetoxy-N-methylamino)quinoline as the main products, with evolution of methane and carbon dioxide. This reaction is discussed in relation to the carcinogenicity and mutagenicity.