Regulation of Hemoglobin Synthesis during the Development of the Red Cell

Publisher Website
Google Scholar
Abstract
(Third of Three Parts)Erythroid Progenitor CellsThe cellular phenomena that occur during the early phases of erythropoiesis involve commitment of progenitor cells to the erythroid pathway and subsequently to the expression of certain individual globin genes. Elucidation of the properties of these cells must precede analysis of the molecular basis of these commitment events.Colony-Forming Unit—ErythroidA means to gain important insights into the mechanism of erythroid differentiation has been provided by the ability to assay erythroid progenitor cells in vitro.353 354 355 356 357 358 359 360 Small colonies containing 8 to 64 nucleated red cells were initially observed in cultures of mouse hematopoietic tissue . . .

This publication has 60 references indexed in Scilit: