Effect of Fluoride on the Activity of Ornithine Decarboxylase in Normal and Fluoride Resistant LS Cells
- 13 March 2009
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 43 (3) , 246-250
- https://doi.org/10.1111/j.1600-0773.1978.tb02261.x
Abstract
Renewal of growth medium caused an induction of ornithine decarboxylase (ODC, EC 4.1.1.17) activity in LS [rat (Lewis) sarcoma cells] cells grown in suspension culture. Addition of low concentrations of fluoride ions to the growth medium (up to 1.3 mM) resulted in a further increase in this induction of ODC-activity, whereas addition of 6 mM fluoride caused an inhibition of the induction and resulted in reduced ODC-activity as compared to controls. Since sodium fluoride had no stimulatory or inhibitory effect on the ODC-activity assay, the effect apparently is exerted on the regulation of ODC-activity in the cells. The effect of fluoride ions on the induction of ODC-activity upon renewal of the growth medium was markedly less pronounced in fluoride resistant LS cells.Keywords
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