Vitamin B Complex and Fat Metabolism

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Abstract
The administration of thiamine, riboflavin, pyridoxine, nicotinic acid and calcium pantothenate to rats on a fat-free, 10% casein, high carbohydrate diet led to the production of fatty livers containing quite a high concentration of cholesterol. When nicotinic acid was absent from this diet the animals developed fatty livers whose cholesterol content, though elevated, was low in comparison with that obtained when nicotinic acid was also fed. Addition of choline to the diet exerted a definite lipotropic action under all conditions studied. However, its effect as a whole was less pronounced in those animals receiving nicotinic acid than in the others.

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