Fatty Livers as a Result of Thiamin Administration in Vitamin B1 Deficiency of the Rat and the Chick
- 1 October 1939
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 18 (4) , 329-338
- https://doi.org/10.1093/jn/18.4.329
Abstract
When thiamin was administered to vitamin B1 deficient chicks or rats hydropic degeneration and fatty metamorphosis occurred in the parenchyma of the liver cells. This histologic reaction in the liver was not prevented by choline, lipocaic or by diets high in fat or in casein. Desiccated thyroid was effective in preventing the histologic reactions in the livers. Chemical analyses on these livers showed that there was an increase in total fat, glycogen and moisture. The phospholipid and protein remained unchanged. Thiamin therapy in experimental vitamin B1 deficiency causes an excessive production of free fat in the liver cell which disrupts the normal cell structure.Keywords
This publication has 10 references indexed in Scilit:
- PHOSPHOLIPID CHANGES DURING THE PRODUCTION OF FATTY LIVERS IN GEESEPublished by Elsevier ,1939
- The Lack of Nerve Degeneration in Uncomplicated Vitamin B1 Deficiency in the Chick and the RatJournal of Nutrition, 1938
- Untoward effects resulting from the use of large doses of vitamin b1Digestive Diseases and Sciences, 1938
- Studies on the Vitamin B1 Requirements Of Growing RatsJournal of Nutrition, 1938
- Studies on the Vitamin B1 Requirements of Growing ChicksJournal of Nutrition, 1938
- THE PHYSIOLOGY OF VITAMIN B1JAMA, 1938
- Vitamin B1 and fatty liversThe Journal of Physiology, 1937
- Pharmakologisches Über Vitamin B1 (Betaxin)Journal of Molecular Medicine, 1937
- THE CARBOHYDRATE METABOLISM OF BRAINPublished by Elsevier ,1936
- Vitamin B1 and Thyroxin.Experimental Biology and Medicine, 1935